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Puberty (precocious)

My 8-year-old daughter was diagnosed with precocious puberty. Her physician is recommending Lupron depot. Has this been effective with other girls with CdLS?

Precocious puberty occurs typically before age 8 in girls. Regarding the treatment, Lupron depot is the only depot treatment (long-acting, pulsatile) used in the US for precocious puberty when the cause is related to the activation of hormones from the brain (hypothalamus/pituitary gland). The treatment prevents the growth spurt to improve final adult height, and also somewhat treats the early puberty symptoms. If your daughter is followed by a pediatric endocrinologist, then I think everything sounds appropriate. I am not aware of this treatment previously in CdLS.

TK 7-13-10



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